IBIS – Inferred Biomolecular Interaction Server

IBIS reports interactions observed in structural complexes of a given protein, and infers binding sites and interacting partners (protein-protein, protein-chemical, protein-nucleic acid, protein-peptide and protein-ion types of interactions) by inspecting protein complexes formed by homologous proteins. Similar binding sites are clustered together based on their sequence and structure conservation. To emphasize biologically relevant binding sites, several algorithms are used for verification in terms of evolutionary conservation, biological importance of binding partners, size and stability of interfaces, as well as evidence from the published literature. Use the server